Relevant laboratory parameters in patients at hospital admission between July 2020 and October 2021 due to covid-19 at the Tesãi Foundation Hospital

Autores/as

DOI:

https://doi.org/10.53732/rccsalud/04.02.2022.27

Palabras clave:

biomarkers, laboratory critical values, COVID-19

Resumen

Background: in the fight against COVID-19, the identification of laboratory predictors in the progression of severe and fatal forms is urgently needed. Aims: to describe the alterations of laboratory parameters of patients diagnosed with COVID-19 at admission to Tesãi Foundation Hospital in Ciudad del Este-Paraguay between July 2020 to October 2021. Methods: A retrospective study using the medical charts of 103 patients admitted to the hospital due to a diagnosis of COVID-19 was carried out. Demographic, clinical, and laboratory data were collected at hospital admission. Results: 53.4% of the patients were male, mean age of 62.3±15.4 years, and 43.6% were admitted due to pneumonia. According to the complete blood count, 54.3% had lymphopenia, 26% thrombocytopenia, and 27% anemia. In the liver and kidney profiles, 37.9% had elevated urea levels, 56.3% elevated GOT levels, 26% elevated GPT, and 61% GGT levels. Regarding biomarkers, 80% had elevated LDH levels, 34% elevated D-dimer levels, 100% elevated C-reactive protein, 43.7% elevated procalcitonin, and 89.3% elevated ferritin. Significant differences (p<0.05) were found according to sex for the parameters of hemoglobin, hematocrit, creatinine, and the LMR ratio. Conclusion: patients presented several alterations in hematological, renal, hepatic, and inflammatory marker parameters, which offer a general overview of the state of health with which the patient with COVID-19 is admitted to the hospital.

Citas

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. https://doi.org/10.1016/S0140-6736(20)30183-5

De Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016;14:523–34. https://doi.org/10.1038/nrmicro.2016.81

Hilgenfeld R, Peiris M. From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Research 2013; 100(1): 286–95. https://doi.org/10.1016/j.antiviral.2013.08.015

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China. N Engl J Med 2019;382:727-33. https://doi.org/10.1056/nejmoa2001017

World Health Organization. Coronavirus Disease 2019 (COVID-19) Situation Report—81. https://apps.who.int/iris/handle/10665/331779

BMJ Best Practice. Coronavirus Disease 2019 (COVID-19). https://bestpractice.bmj.com/topics/en-gb/3000201

Ahn DG, Shin HJ, Kim MH, Lee S, Kim HS, Myoung J, et al. Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). J Microbiol Biotechnol 2020;30(3):313–24. https://doi.org/10.4014/jmb.2003.03011

Chan JF, Yip CC, To KK, Tang TH, Wong SC, Leung KH, et al. Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19- RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens. J Clin Microbiol 2020; 58(5):e00310-20. https://pubmed.ncbi.nlm.nih.gov/32132196/

Ferrari D, Motta A, Strollo M, Banfi G, Locatelli M. Routine blood tests as a potential diagnostic tool for COVID-19. Clin Chem Lab Med. 2020;58(7):1095-1099. https://doi.org/10.1515/cclm-2020-0398

Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847. https://pubmed.ncbi.nlm.nih.gov/32282949/

Zhang JJ, Cao YY, Dong X, Wang BC, Liao MY, Lin J, et al. Distinct characteristics of COVID-19 patients with initial rRT-PCR-positive and rRT-PCR-negative results for SARS-CoV-2. Allergy. 2020;75(7):1809-1812. https://pubmed.ncbi.nlm.nih.gov/32281110/

Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-943. https://doi.org/10.1001/jamainternmed.2020.0994

Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-481. https://doi.org/10.1016/s2213-2600(20)30079-5

Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020;146(1):110-118. https://doi.org/10.1016/j.jaci.2020.04.006

Wang K, Zhang Z, Yu M, Tao Y, Xie M. 15-day mortality and associated risk factors for hospitalized patients with COVID-19 in Wuhan, China: an ambispective observational cohort study. Intensive Care Med. 2020;46(7):1472-1474. https://doi.org/10.1007/s00134-020-06047-w

Asghar MS, Khan NA, Haider Kazmi SJ, Ahmed A, Hassan M, Jawed R, et al. Hematological parameters predicting severity and mortality in COVID-19 patients of Pakistan: a retrospective comparative analysis. J Community Hosp Intern Med Perspect. 2020;10(6):514-520. https://doi.org/10.1080/20009666.2020.1816276

Abadi MSS, Taheri E, Raesi A, Arjmand MH, Kheirii S, Shahinfard N, et al. Procalcitonin as a prognostic factor in patients with COVID-19 in southwestern Iran. Infect Disord Drug Targets. 2022; 22(3):e070122200097. https://doi.org/10.2174/1871526522666220107141109

Cao P, Wu Y, Wu S, Wu T, Zhang Q, Zhang R, et al. Elevated serum ferritin level effectively discriminates severity illness and liver injury of coronavirus disease 2019 pneumonia. Biomarkers. 202;26(3):207-212. https://doi.org/10.1080/1354750x.2020.1861098

Qeadan F, Tingey B, Gu LY, Packard AH, Erdei E, Saeed AI. Prognostic Values of Serum Ferritin and D-Dimer Trajectory in Patients with COVID-19. Viruses. 2021;13(3):419. https://doi.org/10.3390/v13030419

Gao Y, Li T, Han M, Li X, Wu D, Xu Y, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020;92(7):791–6 https://pubmed.ncbi.nlm.nih.gov/32181911/

Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med. 2020;58(7):1131-1134. https://doi.org/10.1515/cclm-2020-0198

World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191-4 https://doi.org/10.1001/jama.2013.281053

Álvarez-Arroyo Laura, Carrera-Hueso Francisco J., El-Qutob David, Robustillo-Villarino Montserrat, Girona-Sanz Ana M., Pin-Godos María T. et al. Estudio descriptivo de una cohorte de pacientes con COVID-19 hospitalizados en España. Gac Méd Méx. 2021;157(1):80-87. https://doi.org/10.24875/gmm.20000605

Montiel D, Torres E, Acosta A, Sobarzo P, Pérez H, Ávalos D, Ramos Y. Características clínicas, laboratoriales y predictores de mortalidad de pacientes con COVID-19 internados en el Hospital Nacional. Rev Cient Cienc Salud. 2021;3(1):26-37. https://doi.org/10.53732/rccsalud/03.01.2021.26

Vera N, Saavedra-Hernández D, Hidalgo-Mesa C, Aguila-López M, Abreu-Gutiérrez G, Herrera-González V, et al. Parámetros de laboratorio clínico en pacientes con la COVID-19. Rev Cub Med Mil. 2021;50(2): e02101171. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572021000200018

Bonnet G, Weizman O, Trimaille A, Pommier T, Cellier J, Geneste L, et al. Critical COVID-19 France Investigators. Characteristics and outcomes of patients hospitalized for COVID-19 in France: The Critical COVID-19 France (CCF) study. Arch Cardiovasc Dis. 2021;114(5):352-363. https://doi.org/10.1016/j.acvd.2021.01.003

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. 10.1056/NEJMoa2002032

Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020; 323(20):2052-2059. https://doi.org/10.1001/jama.2020.6775

Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, et al. Features of 20,133 UK patients in hospital with covid-19 using the ISARIC WHO clinical characterization protocol: prospective observational cohort study. BMJ. 2020; 369:m1985. https://doi.org/10.1136/bmj.m1985

Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline characteristics and outcomes of 1,591 patients infected with SARS CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020; 323(16):1574-1581. https://doi.org/10.1001/jama.2020.5394

Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020; 94:91-5. https://doi.org/10.1016/j.ijid.2020.03.017

Sarhan AR, Hussein TA, Flaih MH, Hussein KR. A Biochemical Analysis of Patients with COVID-19 Infection. Biochem Res Int. 2021; 1383830. https://doi.org/10.1155/2021/1383830

Yuan X, Huang W, Ye B, Chen C, Huang R, Wu F, et al. Changes of hematological and immunological parameters in COVID-19 patients. Int J Hematol. 2020;112(4):553-559. https://doi.org/10.1007/s12185-020-02930-w

Zhu Y, Cao X, Tao G, Xie W, Hu Z, Xu D. The lymph index: a potential hematological parameter for viral infection. Int J Infect Dis. 2013;17(7): e490–e493493. https://doi.org/10.1016/j.ijid.2012.12.002

Rabaan AA, Al-Ahmed SH, Haque S, Sah R, Tiwari R, Malik YS, et al. SARS-CoV-2, SARS-CoV, and MERS-COV: a comparative overview. Le infezioni in medicina. 2020;28(2):174–84. https://pubmed.ncbi.nlm.nih.gov/32275259/

Al-Tawfq JA, Hinedi K, Abbasi S, Babiker M, Sunji A, Eltigani M. Hematologic, hepatic, and renal function changes in hospitalized patients with Middle East respiratory syndrome coronavirus. Int J Lab Hematol. 2017;39(3):272–8. https://pubmed.ncbi.nlm.nih.gov/28444873/

Chu H, Zhou J, Wong BH, Li C, Chan JF, Cheng ZS, et al. Middle East respiratory syndrome coronavirus efciently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. J Infect Dis. 2016;213(6):904–14. https://doi.org/10.1093/infdis/jiv380

Gonze A, Hannesse C, Coppens N, Vellemans H, Maury G. SARS-CoV-2-Induced Severe Immune Thrombocytopenic Purpura. J Med Cases. 2020;11(6):166-168. https://doi.org/10.14740/jmc3481

Chen W, Li Z, Yang B, Wang P, Zhou Q, Zhang Z, et al. Delayed-phase thrombocytopenia in patients with coronavirus disease 2019 (COVID-19). Br J Haematol. 2020;190(2):179-184. https://pubmed.ncbi.nlm.nih.gov/32453877/

Sahu KK, Siddiqui AD, Rezaei N, Cerny J. Challenges for management of immune thrombocytopenia during COVID-19 pandemic. J Med Virol. 2020;92(11):2277-2282. https://pubmed.ncbi.nlm.nih.gov/32619062/

Chen C, Zhou W, Fan W, Ning X, Yang S, Lei Z, Zheng C. Association of anemia and COVID-19 in hospitalized patients. Future Virol. 2021:10.2217/fvl-2021-0044. 10.2217/fvl-2021-0044

Huang D, Yang H, Yu H, Wang T, Chen Z, Zongan L, Rong Y. Blood Urea Nitrogen to Serum Albumin Ratio (BAR) Predicts Critical Illness in Patients with Coronavirus Disease 2019 (COVID-19). Int J Gen Med. 2021;14:4711–21. https://doi.org/10.2147/ijgm.s326204

Kumar-M P, Mishra S, Jha DK, Shukla J, Choudhury A, Mohindra R, et al. Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis. Hepatol Int. 2020;14(5):711–22. https://doi.org/10.1007/s12072-020-10071-9

Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;58(7):1021-1028. https://doi.org/10.1515/cclm-2020-0369

Ponti G, Maccaferri M, Ruini C, Tomasi A, Ozben T. Biomarkers associated with COVID-19 disease progression. Crit Rev Clin Lab Sci. 2020;57(6):389–99. https://doi.org/10.1080/10408363.2020.1770685

Tan C, Huang Y, Shi F, Tan K, Ma Q, Chen Y, et al. C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early. J Med Virol. 2020;92(7):856-862. https://pubmed.ncbi.nlm.nih.gov/32281668/

Tang N, Li D, Wang X. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844–847. https://pubmed.ncbi.nlm.nih.gov/32073213/

Lippi G, Favaloro EJ. D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis. Thromb Haemost. 2020;120(5):876-878. https://doi.org/10.1055/s-0040-1709650

Martins EC, Silveira LDF, Viegas K, Beck AD, Fioravantti Júnior G, Cremonese RV, et al. Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study. Rev Bras Ter Intensiva. 2019;31(1):64-70. https://doi.org/10.5935/0103-507x.20190010

Lee JS, Kim NY, Na SH, Youn YH, Shin CS. Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine (Baltimore). 2018;97(26): e11138. https://journals.lww.com/md-journal/Fulltext/2018/06290/Reference_values_of_neutrophil_lymphocyte_ratio,.21.aspx

Asghar MS, Khan NA, Haider Kazmi SJ, Ahmed A, Hassan M, Jawed R, et al. Hematological parameters predicting severity and mortality in COVID-19 patients of Pakistan: a retrospective comparative analysis. J Community Hosp Intern Med Perspect. 2020;10(6):514-520. https://doi.org/10.1080/20009666.2020.1816276

Bergamaschi G, Borrelli de Andreis F, Aronico N, Lenti MV, Barteselli C, Merli S. Internal Medicine Covid-19 Collaborators. Anemia in patients with Covid-19: pathogenesis and clinical significance. Clin Exp Med. 2021;21(2):239-246. https://doi.org/10.1007/s10238-020-00679-4

Lissoni P, Rovelli F, Monzon A, Privitera C, Messina G, Porro G et al. Evidence of Abnormally Low Lymphocyte-To-Monocyte Ratio In Covid-19-Induced Severe Acute Respiratory Syndrome. J Immuno Allerg. 2020;1(2):1-6. http://dx.doi.org/10.37191/Mapsci-2582-6549-1(2)-011

Descargas

Publicado

2022-10-28

Cómo citar

1.
Villanueva González DM, Meza Miranda ER. Relevant laboratory parameters in patients at hospital admission between July 2020 and October 2021 due to covid-19 at the Tesãi Foundation Hospital. Rev. cient. cienc. salud [Internet]. 28 de octubre de 2022 [citado 24 de noviembre de 2024];4(2):27-3. Disponible en: https://upacifico.edu.py:8043/index.php/PublicacionesUP_Salud/article/view/289