Clinical and demographic characteristics of patients with deep vein thrombosis in a referral hospital in Paraguay during the COVID-19 pandemic (2020-2023)

Authors

DOI:

https://doi.org/10.53732/rccsalud/2024.e6152

Keywords:

deep vein thrombosis, Covid-19, anticoagulants, low molecular weight heparin, risk factors

Abstract

Introduction. Venous thromboembolic disease, which includes deep vein thrombosis (DVT), is the third most common cardiovascular disease worldwide, with significant morbidity and mortality. Objective. To describe the clinical and demographic characteristics of patients with Deep Vein Thrombosis (DVT) admitted to a referral hospital in Paraguay during the COVID-19 pandemic (2020-2023). Materials and methods. Observational, descriptive, retrospective, cross-sectional study. 80 patients over 18 years of age with a confirmed diagnosis of DVT were included, selected by non-probabilistic sampling of consecutive cases. Demographic, clinical, and treatment data were collected from medical records. Results. The mean age was 52 ± 17 years, with a predominance of females (55%, 95% CI: 44-66%). COVID-19 disease was the most frequent underlying pathology (29%, 95% CI: 19-39%). According to the Wells scale, 62.5% (95% CI: 51-73%) presented moderate risk of DVT. Limb asymmetry (65%, 95% CI: 54-75%) and calf pain (61.25%, 95% CI: 50-72%) were the most frequent symptoms. 72.5% (95% CI: 62-82%) received low molecular weight heparin during hospitalization. Conclusion. DVT in this center predominantly affected middle-aged women, with COVID-19 as an emerging risk factor. These findings underline the need for active surveillance of DVT in patients with COVID-19 and suggest the importance of prevention and treatment strategies adapted to the pandemic context in Paraguay.

References

Sandino VM, Vega EV. Abordaje de trombosis venosa profunda en miembros inferiores. Revista Medica Sinergia. 2020;5(2):e360-e360. https://doi.org/10.31434/rms.v5i2.360

García Fajardo JD, Bolaño Vaillant S, Dosouto Infante V, Flores Ramírez I, Pascual Díaz JD, et al. Ecografía Doppler en el diagnóstico de trombosis venosa profunda de miembros inferiores. Multimed. 2020;24(6):1271-82. https://www.medigraphic.com/pdfs/multimed/mul-2020/mul206d.pdf

Muñoz Rodríguez FJ. Diagnóstico de la trombosis venosa profunda. Revista Clínica Española. 2020;220:41-9. https://doi.org/10.1016/j.rce.2020.03.009

García-Gómez MA, García-Pérez J, Colorado-Cruz MF, López-Burgos CP, López-Zamora B, León-Pérez KM, et al. Ethiology, risk factors and Whole blood viscosity index in thromboembolic venous disease. Rev Med Inst Mex Seguro Soc. 2023;61(2):140-6. https://pubmed.ncbi.nlm.nih.gov/37200530/

Áinle FN, Kevane B. Which patients are at high risk of recurrent venous thromboembolism (deep vein thrombosis and pulmonary embolism)? Blood Adv. 2020;4(21):5595-606. https://doi.org/10.1182/bloodadvances.2020002268

Alonso-Beato R, Lago-Rodríguez MO, López-Rubio M, Gómez-Tórtola A, García-Fernández-Bravo I, Oblitas CM, et al. Risk of thrombosis recurrence among patients with COVID-19 and surgery-associated venous thromboembolism. Rev Clin Esp (Barc). 2023;223(5):255-61. https://doi.org/10.1016/j.rceng.2023.03.003

Bustillo Santandreu M de J, Álvarez López Y, Feíto Castex TR, García Seco F, Montes de Oca García Y, González Bustillo EA, et al. Morbi-mortalidad de la enfermedad tromboembólica venosa en el Hospital Universitario “Arnaldo Milián Castro”. Revista Cubana de Angiología y Cirugía Vascular. 2022;23(1). https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=113819

Marini CP, Lewis E, Petrone P, Zenilman A, Lu Z, Rivera A, et al. Incidence and effects of deep vein thrombosis on the outcome of patients with coronavirus disease 2019 infection. J Vasc Surg Venous Lymphat Disord. 2022;10(4):803-10. https://doi.org/10.1016/j.jvsv.2021.10.013

Cosmi B, Borgese L, Legnani C, Sartori M, Palareti G. Sex Differences in Clinical Presentation of Lower Extremity Deep Vein Thrombosis. J Women’s Health. 2024;33(6):758-64. https://doi.org/10.1089/jwh.2023.0450

Chan SM, Brahmandam A, Valcarce-Aspegren M, Zhuo H, Zhang Y, Tonnessen BH, et al. Sex differences in long-term outcomes of patients with deep vein thrombosis. Vascular. 2023;31(5):994-1002. https://doi.org/10.1177/17085381221097746

Wilcox T, Smilowitz NR, Seda B, Xia Y, Hochman J, Berger JS. Sex Differences in Thrombosis and Mortality in Patients Hospitalized for COVID-19. The American Journal of Cardiology. 2022;170:112-7. https://doi.org/10.1016/j.amjcard.2022.01.024

Saliba Júnior OA, Alves AFDJ, Matarazzo C, Gonçalves GT, Sobreira ML. Trombose venosa profunda de membros inferiores em pacientes com covid-19. J vasc bras. 2023;22:e20230027. https://doi.org/10.1590/1677-5449.202300271

Yamashita Y, Yachi S, Takeyama M, Nishimoto Y, Tsujino I, Nakamura J, et al. Significant Impact of Age on Mortality and Non-significant Impact of Age on Thrombosis and Major Bleeding in Patients with COVID-19: From the CLOT-COVID Study. J Atheroscler Thromb. 2023;30(6):624-35. https://doi.org/10.5551/jat.63702

Currey J, Ellsworth C, Khatun MS, Wang C, Chen Z, Liu S, et al. Upregulation of inflammatory genes and pathways links obesity to severe COVID-19. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2024;1870(7):167322. https://doi.org/10.1016/j.bbadis.2024.167322

Lobanova KG, Skuridina DV, Bairova VE. Pathophysiological aspects of the effect of obesity on the course of viral diseases. FOCUS. Endocrinology. 2024;5(2):46-51. https://doi.org/10.62751/2713-0177-2024-5-2-17

Mancuso P. Obesity and Respiratory Infections Including COVID-19. En: Dixon AE, Forno E, editores. Obesity and Lung Disease. Cham: Springer International Publishing; 2024. 301-20. Respiratory Medicine. https://link.springer.com/10.1007/978-3-031-52696-1_15

Reddy A, Savlania A, Naik A, Rastogi P, Gorsi U. Deep venous thrombosis manifestation of common femoral vein leiomyoma. annals. 2020;102(6):e141-4. https://doi.org/10.1308/rcsann.2020.0062

Baroncini LAV, Franca GJ, Oliveira AD, AntonioVidal E, Valle CED, Stahlke PSDB, et al. Correlation of clinical features with the risk of lower limb deep vein thrombosis assessed by duplex ultrasound. J vasc bras. 2013;12(2):118-22. https://doi.org/10.1590/S1677-54492013000200005

Link D. Late Complications of Deep Venous Thrombosis: Painful Swollen Extremities and Non Healing Ulcers. En: Okuyan E, editor. Venous Thrombosis - Principles and Practice. InTech; 2012. https://doi.org/10.5772/26726

Gibson K, Nicolini P. Up to Date Guidance for the Clinical Management of Chronic Venous Disease. Eur J Vasc Endovasc Surg. 2022;63(2):179-80. https://doi.org/10.1016/j.ejvs.2022.01.019

Rognoni C, Lugli M, Maleti O, Tarricone R. Clinical guidelines versus current clinical practice for the management of deep vein thrombosis. J Vasc Surg Venous Lymphatic Disord. 2021;9(5):1334-1344.e1. https://doi.org/10.1016/j.jvsv.2021.01.020

Kumar AH. Comparative Pharmacology of Direct Oral Anticoagulants and Vitamin K Antagonist. BEMS Reports. 2022;8(2):16-23. https://doi.org/10.5530/bems.8.2.5

Published

2024-10-30

How to Cite

Alfonso Balbuena, T., & Serna Cuellar, A. (2024). Clinical and demographic characteristics of patients with deep vein thrombosis in a referral hospital in Paraguay during the COVID-19 pandemic (2020-2023). Revista científica Ciencias De La Salud, 6, 01–07. https://doi.org/10.53732/rccsalud/2024.e6152