Efecto de la cirugía bariátrica sobre el metabolismo de lipoproteínas ricas en triglicéridos
DOI:
https://doi.org/10.53732/rccsalud/01.01.2019.57Keywords:
Obesidad, cirugía bariátrica, insulinoresistencia, triglicéridos, lipoproteínas ricas en triglicéridosAbstract
La resistencia a la insulina, la diabetes tipo 2 y la obesidad, se caracterizan por un aumento en las lipoproteínas ricas en triglicéridos debido a la reducción del catabolismo de TRL de la circulación y al aumento de la producción hepática (apoB-100 que contiene VLDL) e intestinal (apoB-48 que contiene quilomicrones). La cirugía bariátrica es el único tratamiento actualmente que provoca a una pérdida de peso marcada y sostenida. Aquí, repasaremos los efectos de la cirugía bariátrica en los triglicéridos circulantes / TRL La cirugía bariátrica conduce a una marcada reducción de triglicéridos en ayuno y posprandial. Los datos disponibles sugieren que la cirugía bariátrica reduce la producción de triglicéridos y TRL intestinal y hepático con una mayor depuración de las partículas hepáticas de TRL. Algunos estudios de cirugía bariátrica han reportado una correlación débil entre la pérdida de peso y las mejoras en triglicéridos / TRL, lo que sugiere que factores como GLP-1 más allá de la pérdida de peso pueden contribuir a los cambios marcados en TRL que ocurren posterior a la cirugía posbariátrica. También se necesitan estudios adicionales para comparar los efectos de diversos procedimientos de cirugía bariátrica en la cinética de TRL para dilucidar los mecanismos subyacentes.
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