Histiocitosis de células de langerhans. Un hallazgo poco común en la glándula tiroides. A propósito de un caso
DOI:
https://doi.org/10.53732/rccsalud/03.02.2021.102Palabras clave:
histiocitosis de células de langerhans, tiroides, neoplasiaResumen
La histiocitosis de células de Langerhans (HCL) es una neoplasia mieloide, poco común, se caracteriza por la proliferación de células histiocíticas CD1a+/Langerina+. La incidencia en adultos es 1 a 2 casos por millón, un poco más frecuente en niños. La presentación es variable, como una única lesión en un órgano hasta una enfermedad multisistémica con toque de órganos vitales. Los tejidos de mayor afinidad son: huesos, piel, pulmones e hipófisis y raramente tiroides. El retraso en el diagnóstico o en el tratamiento puede provocar un deterioro de la función de los órganos afectados. El objetivo de la comunicación es reportar un caso de HCL, de presentación aún menos frecuente, en forma aislada en la glándula tiroides de un adulto, hallazgo hecho tras una tiroidectomía total, realizándose el diagnóstico luego de la histología.
Citas
Kobayashi. M, Arinobu T. Langerhans cell histiocytosis in adults: Advances in pathophysiology and treatment. Cancer science. 2018;109:12: 3707-13. Doi:10.1111/cas.13817
Berres ML, Lim KP, Peters T, et al. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. J Exp Med. 2014;211(4):669-83. Doi: http://dx.doi.org/10.1084/jem.20130977.
Badalian-Very G, Vergilio A,Degar B et al. Recent advances in the understanding of Langerhans cellhistiocytosis. Gayane British Journal of Haematology 2011, 156, 163–172. Doi: 10.1111/j.1365-2141.2011.08915
Allen CE, Merad M, McClain KL. Langerhans-Cell Histiocytosis. N Engl J Med. 2018 Aug 30;379(9):856-68. Doi: http://dx.doi.org/10.1056/NEJMra1607548.
Al Hamad M, Albisher HM, Al Saeed WR, Almumtin AT, Allabbad FM, A Shawarby M. BRAF gene mutations in synchronous papillary thyroid carcinoma and Langerhans cell histiocytosis co-existing in the thyroid gland: a case report and literature review. BMC Cancer. 2019 Feb 22;19(1):170. Doi: http://dx.doi.org/10.1186/s12885-019-5372-3.
Guyot-Goubin A, Donadieu J, Barkaoui M, Bellec S, Thomas C, Clavel J. Descriptive epidemiology of childhood Langerhans cell histiocytosis in France, 2000-2004. Pediatr Blood Cancer 2008;51(1):71–5. Doi: 10.1002/pbc.21498
Aricó M, Girschikofsky M, Généreau T, et al. Langerhans cell histiocytosis in adults: report from the International Registry of the Histiocyte Society. Eur J Cancer 2003;39(16):2341. Doi: 10.1016/s0959-8049(03)00672-5
Venkatramani R, Rosenberg S, Indramohan G, Jeng M, Jubran R. An exploratory epidemiological study of Langerhans cell histiocytosis. Pediatr Blood Cancer 2012;59(7):1324–6. Doi: http://dx.doi.org/10.1002/pbc.24136
Ben Nacef I, Mekni S, Mhedhebi C, Riahi I, Rojbi I, Nadia M, Khiari K. Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form. Case Rep Endocrinol. 2020 Mar 17;2020:6284764. Doi: http://dx.doi.org/10.1155/2020/6284764.
Wang FF, Liu YS, Zhu WB, Liu YD, Chen Y. Pulmonary Langerhans cell histiocytosis in adults: A case report. World J Clin Cases. 2019;7(14):1892-1898. Doi: http://dx.doi.org/10.12998/wjcc.v7.i14.1892
Emile JF, Charlotte F, Chassagne-Clement C, Copin MC, Fraitag S, Mokhtari K, Moreau A. Classification histologique et altérations moléculaires des histiocytoses. Presse Med. 2017 Jan;46(1):46-54. Doi: https://doi.org/10.1016/j.lpm.2016.01.016
Patten DK, Wani Z, Tolley N. Solitary langerhans histiocytosis of the thyroid gland: a case report and literature review. Head Neck Pathol. 2012 Jun;6(2):279-89. Doi: http://dx.doi.org/10.1007/s12105-011-0321-8
Kim IK, Lee KY. Adult Langerhans cell histiocytosis of skull in a patient with synchronous papillary thyroid carcinoma and Castleman disease. BMJ Case Reports CP 2021;14(1):e239341. Doi: 10.1136/bcr-2020-239341
Chrisoulidou A, Xirou P, Boudina M, Margaritidou E, Patakiouta F. Images in Endocrine Pathology: Isolated Langerhans Cell Histiocytosis of the Thyroid in a Patient with Autoimmune Thyroiditis and Hyperthyroidism. Endocr Pathol. 2015;26(3):276-278. Doi: http://dx.doi.org/10.1007/s12022-015-9369-4
Saqi A, Kuker AP, Ebner SA, et al. Langerhans Cell Histiocytosis: Diagnosis on Thyroid Aspirate and Review of the Literature. Head Neck Pathol. 2015;9(4):496-502. Doi: http://dx.doi.org/10.1007/s12105-015-0608-2.
Pandyaraj RA, Sathik Mohamed Masoodu K, Maniselvi S, Savitha S, Divya Devi H. Langerhans cell histiocytosis of thyroid-a diagnostic dilemma. Indian J Surg. 2015;77(Suppl 1):49-51. Doi: http://dx.doi.org/10.1007/s12262-014-1118
Girschikofsky M, Arico M, Castillo D, et al. Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net. Orphanet J Rare Dis. 2013;8:72. 2013 May 14. Doi: http://dx.doi.org/10.1186/1750-1172-8-72
Montella L, Insabato L, Palmieri G. Imatinib mesylate for cerebral Langerhans cell histiocytosis. N Engl J Med. 2004;351:1034-1035. Doi: http://dx.doi.org/10.1056/NEJM200409023511022
Wagner C, Mohme H, Krömer-Olbrisch T, et al. Arch Dermatol. 2009;145(8):949. Doi: 10.1001/archdermatol.2009.164
Haroche J, Cohen-Aubart F, Emile JF, et al. Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation. Blood. 2013;121(9):1495-1500. Doi: 10.1182/blood-2012-07-446286
Foulet-Rogé A, Josselin N, Guyetant S, et al. Incidental langerhans cell histiocytosis of thyroid: case report and review of the literature. Endocr Pathol. 2002;13(3):227-33. http://dx.doi.org/10.1385/EP:13:3:227.
Thompson LD, Wenig BM, Adair CF, Smith BC, Heffess CS. Langerhans cell histiocytosis of the thyroid: a series of seven cases and a review of the literature. Mod Pathol. 1996;9(2):145-149. Disponible en: https://pubmed.ncbi.nlm.nih.gov/8657721/
Dursun A, Pala EE, Ugurlu L, Aydin C. Primary Langerhans Cell Histiocytosis in Thyroid. Acta Endocrinol (Buchar). 2020;16(4):501-504. Doi: http://dx.doi.org/10.4183/aeb.2020.501
Lo WC, Chen CC, Tsai CC, Cheng PW. Isolated adult Langerhans' cell histiocytosis in cervical lymph nodes: should it be treated?. J Laryngol Otol. 2009;123(9):1055-1057. Doi: http://dx.doi.org/10.1017/S0022215108004155.
Maraqa B, Al-Ashhab M, Kamal N, El Khaldi M, Sughayer M. Concomitant Langerhans cell histiocytosis of cervical lymph nodes in adult patients with papillary thyroid carcinoma: A report of two cases and review of the literature. Autops Case Rep. 2021;11:e2021253. 2021 Mar 12. Doi: http://dx.doi.org/10.4322/acr.2021.253
Ozisik H, Yurekli BS, Demir D, Ertan Y, Simsir IY, Ozdemir M, Erdogan M, Cetinkalp S, Ozgen G, Saygili F. Langerhans cell histiocytosis of the thyroid together with papillary thyroid carcinoma. Hormones (Athens). 2020 Jun;19(2):253-259. Doi: http://dx.doi.org/10.1007/s42000-020-00181-2.
He Y, Xie J, Zhang H, Wang J, Su X, Liu D. Delayed Diagnosis of Langerhans Cell Histiocytosis Presenting With Thyroid Involvement and Respiratory Failure: A Pediatric Case Report. J Pediatr Hematol Oncol. 2020 Nov;42(8):e810-e812. Doi: http://dx.doi.org/10.1097/MPH.0000000000001625.
Xie J, Li Z, Tang Y. Successful management of multiple-systemic Langerhans cell histiocytosis involving endocrine organs in an adult: A case report and review of literature. Medicine (Baltimore). 2018 Jun;97(26):e11215. Doi: http://dx.doi.org/10.1097/MD.0000000000011215.
Kuhn E, Ragazzi M, Zini M, Giordano D, Nicoli D, Piana S. Critical Pitfalls in the use of BRAF Mutation as a Diagnostic Tool in Thyroid Nodules: a Case Report. Endocr Pathol. 2016 Sep;27(3):220-3. Doi: http://dx.doi.org/10.1007/s12022-016-9414-y.
Skowronska-Jozwiak E, Sporny S, Szymanska-Duda J, Baranska D, Lewinski A. Hypopituitarism and goitre as endocrine manifestation of Langerhans cell histiocytosis (LCH). Case Report. Neuro Endocrinol Lett. 2016 Jul;37(3):174-178. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27618599/
Attakkil A, Thorawade V, Jagade M, Kar R, Parelkar K. Isolated Langerhans Histiocytosis in Thyroid: Thyroidectomy or Chemotherapy? J Clin Diagn Res. 2015 Sep;9(9):XD01-XD03. doi: http://dx.doi.org/10.7860/JCDR/2015/12313.6466.
Sangtian J, Riangwiwat T, Triamchaisri S, Kanoksil W, Sriphrapradang C. Fine-needle aspiration biopsy of langerhans cell histiocytosis of thyroid gland. J Clin Endocrinol Metab. 2015 Jan;100(1):15-6. Doi: http://dx.doi.org/10.1210/jc.2014-2859.
Roy M, Jain D, Bakhshi S, Mathur S, Iyer VK. Primary Langerhans cell histiocytosis of the thyroid gland: role of langerin in FNA cytological diagnosis. Cytopathology. 2015 Apr;26(2):128-30. Doi: http://dx.doi.org/10.1111/cyt.12142.
Long Q, Shaoyan W, Hui W. 18F-fluorodeoxyglucose positron emission tomography/computed tomography for primary thyroid langerhans histiocytosis: A case report and literature review. Indian J Nucl Med. 2015 Oct-Dec;30(4):328-30. Doi: http://dx.doi.org/10.4103/0972-3919.159688.
Oza N, Sanghvi K, Menon S, Pant V, Patil M, Kane S. Cytological Diagnostic Approach in 3 Cases of Langerhans Cell Histiocytosis Presenting Primarily as a Thyroid Mass. Acta Cytol. 2015;59(5):418-24. Doi: http://dx.doi.org/10.1159/000440969.
Cai YF, Wang QX, Ni CJ, Dong SY, Lv L, Li Q, Chen ED, Zhang XH. A Case Report: The Diagnosis and Therapeutic Evaluation for a Rare Disease of Langerhans Cell Histiocytosis Involving Thyroid. Medicine (Baltimore). 2015 Nov;94(44):e1891. Doi: http://dx.doi.org/10.1097/MD.0000000000001891.
Diego E, Biagetti B, Iglesias C, González O, Mesa J. Histiocitosis de células de Langerhans asociada a carcinoma papilar de tiroides. Rev Clin Esp (Barc). 2014 Mar;214(2):e19-21. Spanish. Doi: http://dx.doi.org/10.1016/j.rce.2013.11.005.
Marupudi KC, Karanth SS, Thomas J. Langerhans cell histiocytosis presenting as hypothyroid goitre: a unique presentation. BMJ Case Rep. 2014 Dec 2;2014:bcr2014206760. doi: http://dx.doi.org/10.1136/bcr-2014-206760.
Chen WZ, Lv YX, Xu DB, Chen WZ, Yu JC. [Langerhans cell histiocytosis of the thyroid: a case report]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Mar 5;31(5):397-399. Doi: http://dx.doi.org/10.13201/j.issn.1001-1781.2017.05.018.
Znati K, Sekal M, Chbani L, Elfatemi H, Harmouch T, Amarti A. Cause très rare de goitre diffus [Very rare cause of diffuse goiter]. Ann Pathol. 2013 Oct;33(5):352-4. Doi:
http://dx.doi.org/10.1016/j.annpat.2013.08.002.
Pusztaszeri MP, Sauder KJ, Cibas ES, Faquin WC. Fine-needle aspiration of primary Langerhans cell histiocytosis of the thyroid gland, a potential mimic of papillary thyroid carcinoma. Acta Cytol. 2013;57(4):406-12. Doi: http://dx.doi.org/.1159/000348801.
.png)
Todo el contenido de esta revista, está bajo 